HEALTH
The study by researchers at University of Pennsylvania in the US found evidence that the sons of fathers that ingested cocaine prior to conception struggle to make new memories.
Fathers who use cocaine at the time of conceiving a child may be putting their sons at risk of learning disabilities and memory loss, a new study has warned.
The findings reveal that drug abuse by fathers - separate from the well-established effects of cocaine use in mothers - may negatively impact cognitive development in their male offspring, researchers said.
The study by researchers at University of Pennsylvania in the US found evidence that the sons of fathers that ingested cocaine prior to conception struggle to make new memories.
Their findings demonstrated that the sons - but not the daughters - of male rats that consumed cocaine for an extended period of time could not remember the location of items in their surroundings and had impaired synaptic plasticity in hippocampus, a brain region critical for learning and spatial navigation in humans and rodents.
"These results suggest that the sons of male cocaine addicts may be at risk for learning deficits," said R Christopher Pierce, professor at the University of Pennsylvania.
Pierce and his colleagues propose that epigenetic mechanisms are at the root of the problem. Epigenetics refers to heritable traits that are not caused by changes in the DNA sequence, as is the case with genetic inheritance.
DNA is tightly wound around proteins called histones, like thread around a spool and chemical changes to histones influence the expression of genes, which is an epigenetic process.
The research showed that cocaine use in dads caused epigenetic changes in the brain of their sons, thereby changing the expression of genes important for memory formation.
D-serine, a molecule essential for memory, was depleted in male rats whose father took cocaine and replenishing the levels of D-serine in the sons' hippocampus improved learning in these animals.
The researchers showed that cocaine abuse in dads broadly altered the chemical marks on histones in the brain of their sons, even though the offspring were never exposed to cocaine.
Chemical modifications on the histones were changed to favour active transcription of genes in the hippocampus of male rats with a paternal history of cocaine taking, allowing more production of the enzyme D-amino acid oxidase, which degrades D-serine.
The researchers propose that increased expression of the enzyme, driven by changes in the epigenetic landscape, cause the memory problems in the sons of addicted rats.
"There is substantial interest in the development of D-serine and related compounds, which are well tolerated by humans, as drug therapies," Pierce said.
"The ability of D-serine to reverse the adverse effects of paternal cocaine taking on learning adds potential clinical relevance to our research," he added.
The findings were published in the journal Molecular Psychiatry.
(This article has not been edited by DNA's editorial team and is auto-generated from an agency feed.)
IND vs NZ, 2nd Test Dream11 prediction: Fantasy cricket tips for India vs New Zealand match
How To Prepare For The UPSC CSE 2025 Exam?
'India supports dialogue and diplomacy, not war': PM Modi at BRICS Summit
This woman lost in Dubai's desert orders camel via Uber, netizens say 'your camel has arrived'
Good news for Vijay Shekhar Sharma, Paytm gets NPCI nod to..., shares surge over 7%
Fan requests Rohit Sharma to deliver her message to Virat Kohli, here's how Indian captain responded
Rajkummar Rao recalls being scammed in Delhi during struggle days: 'The man had...'
Robbers pose as customers in jewellery shop, what owner did next will leave you shocked
Maharashtra Elections 2024: NCP releases 1st list of 38 candidates; Ajit Pawar to contest from…
Japanese Shah Rukh Khan leaves Bollywood Badshah's fan impressed, social media says...
Will KL Rahul be retained by LSG ahead of IPL Auction? New report provides BIG update, it says...
'Wayanad will have two MPs': Rahul Gandhi after Priyanka files nomination for bypolls
I Want To Talk teaser: Abhishek Bachchan announces his next with Shoojit Sircar, to release on...
Diwali 2024: When is Deepawali, October 31 or November 1? Check dates, mahurat timings and more
JEE Main 2025 exam date to release TODAY: Know how to register, check exam calendar HERE
Jhalmuri fever hits London: Video of British man selling Kolkata-style street food goes viral, watch
SC slams Centre as Delhi air worsens, calls environment laws...
Ex-cricketer suggests replacing KL Rahul with THIS batsman for 2nd Test vs NZ, he is…
TMC MP Kalyan Banerjee smashes bottle, hurls it towards Chair in row over Waqf meet
Know how Mukesh Ambani and Nita Ambani's children Isha Ambani and Akash Ambani got their names
Family finds venomous snakes under their bed, what happened next will leave you in shock
This company's Vice President gets fired after raise and bonus, reason will leave you shocked
Mukesh Ambani-led Jio Financial eyes JVs with Allianz SE in insurance sector
IMD's BIG update: Cyclone Dana forms over Bay of Bengal, to cross Odisha-Bengal coasts on...
This company gifts cars as Diwali bonus, calls its employees celebrities, is owned by…
Amid divorce rumours with Aishwarya Rai, Abhishek Bachchan skips her family gathering
When Ratan Tata opened up about his parents separation, first love and childhood, he said...
Blow to Mukesh Ambani ahead of Isha Ambani, Akash Ambani's birthday, Reliance stocks...
Saudi Arabia's futuristic megacity project Neom a big threat to migratory birds? Experts say...
Apple CEO Tim Cook didn’t know about this iPhone feature, left speechless, know here
Mukesh Ambani's Reliance Jio offers superhit Diwali plan, unlimited 5G internet for just Rs...
Bengaluru Rains: Schools closed, WFH advisory for private companies as IMD issues yellow alert
Israel confirms killing of Hashem Safieddine, presumed successor of Hezbollah chief Hassan Nasrallah
Big move by Anil Ambani, his company to invest Rs 10000 crore to set up India's largest...
Meet Indian genius, who was born in small town, today leads AI innovations of Google, she is...
Woman stays at luxury resort worth Rs 3 lakh for free, claims she used...
Delhi AQI update: Air quality worsens to 'very poor' level at 349, becomes 'severe' in these areas
PM Modi to hold bilateral talks with Xi Jinping at BRICS Summit today
Odisha, West Bengal brace for Cyclone Dana: How was it named and what it means?
POCSO case: Mumbai Police ask Ekta Kapoor, her mother to appear for questioning tomorrow
Watch: Can you identify all the actors in this clip from 1991?
Priyanka Gandhi to file nomination for Wayanad Lok Sabha bypoll today
Meet woman, whose father used to sell milk, cracked UPSC exam with AIR 62 to become...
Delhi: No water supply in Capital for 12 hours on Friday due to…; check list of affected areas
Salman Khan resumes shooting for Sikandar amid death threats from Lawrence Bishnoi
India, Pakistan extend Kartarpur Sahib corridor agreement for five years
DNA TV Show: What is BRICS currency? Is it possible to introduce it today?
IPL 2025: Three-time IPL champion set to join Gujarat Titans as batting coach - Reports
PM Modi, Xi Jinping to hold bilateral meet on sidelines of BRICS Summit on Oct 23, first in 5 years
New Himalayan snake species named after Academy Award winner Leonardo DiCaprio, it will be called…
Cyclone Dana: Schools closed in West Bengal, Odisha for 4 days from...
Delhi govt to provide special assistance of Rs 5000 monthly to...
Rape-accused Hollywood producer Harvey Weinstein diagnosed with bone marrow cancer
IND vs NZ: Sarfaraz Khan or KL Rahul; Who will find a spot in 2nd Test? India coach says…
Mumbai Police interrogates Ekta Kapoor, her mother Shobha Kapoor in case under POCSO act
Mukesh Ambani may team up with govt to sell food products through...
Bengaluru: Several feared trapped as under-construction building collapses
Best Cheap VPS Hosting Providers: Top Picks for Hosting Under USD 10
Zomato CEO Deepinder Goyal set to raise Rs 8500 crore, says it is meant to...