The 42-year-old actress underwent surgery in New York on December 10, 2012, and was discharged from the hospital after 11 days.
"Today is my first chemo... between being nervous of unknown and courage to face the challenge, I am in a state of prayer and in gratitude of the support I have received from mom, dad, koi, Yulia though she is far but her love and prayers do touch me... and so many other loving friends and family," Manisha posted on Facebook.
"Thank you for your love and prayers... nothing else is more important than love and care... thank you... until next time," she added.
Manisha, who was detected with cancer in early December, has been living in the US ever since for treatment.
"Missing home, my friends... missing being healthy and fit... one day at a time... one moment at a time, one breath at a time... one step at a time," she posted on the social networking site today.
She is also drawing inspiration from actress Lisa Ray, who has completely recovered from multiple myeloma and is living a happy married life now.
"Got a chemo cut... thank you Lisa Ray for this term... in fact thank you or your blog, thank you for your honesty and boldness... God bless you," tweeted Manisha.
Lisa, who was diagnosed with cancer in 2009, has been very vocal and spirited about her battle with the disease.