Known affectionately as "Gabo", the author of One Hundred Years of Solitude and Love in the Time of Cholera was one of the world's most popular Latin American novelists and the godfather of a literary movement that witnessed a continent in turmoil.
The longtime journalist was a colorful character who befriended Cuban leader Fidel Castro, got punched by fellow Nobel laureate Mario Vargas Llosa and joked that he wrote to make his friends love him.
Presidents, writers and celebrities mourned his death, the cause of which was not immediately revealed.
"One thousand years of solitude and sadness for the death of the greatest Colombian of all time," Colombian President Juan Manuel Santos wrote on Twitter.
He later declared three days of national mourning.
"The world has lost one of its greatest visionary writers," United States President Barack Obama said.
Garcia Marquez had made fewer public appearances in recent years. He was hospitalized for pneumonia on March 31 and discharged to recover at his Mexico City home.
His wife Mercedes and two sons were reportedly by his side at home when he died. A hearse later took his body to a funeral home under police escort.
Born March 6, 1927, in the village of Aracataca on Colombia's Caribbean coast, Garcia Marquez was the son of a telegraph operator. He was raised by his grandparents and aunts in a tropical culture influenced by the heritage of Spanish settlers, indigenous populations and black slaves. His grandfather was a retired colonel.
The exotic legends of his homeland inspired him to write profusely. His masterpiece, One Hundred Years of Solitude, was translated into 35 languages and sold more than 30 million copies.
The book, published in 1967, is a historical and literary saga about a family from the imaginary Caribbean village of Macondo between the 19th and 20th century – a novel that turned the man with the mustache and thick eyebrows into an international star.
'Without a penny'
Garcia Marquez wrote the novel after moving to Mexico City in 1961, taking a long bus ride from New York with his wife, Mercedes Barcha, and son Rodrigo.
His second son, Gonzalo, was born a year later in the Mexican capital, where the author lived for more than three decades.
He recalled arriving in Mexico City "without a name or a penny in my pocket". The writer faced financial hardship, working for advertising agencies, penning screenplays and editing small magazines.
"As long as there was whisky, there was no misery," Garcia Marquez quipped.
The novelist owed nine months of rent payments when he penned One Hundred Years of Solitude and could barely afford to send the manuscript to his editor in Argentina.
Garcia Marquez wore a traditional white liqui-liqui costume with a high collar from his region to receive his Nobel prize in Sweden in 1982.
The Nobel committee rewarded him for books "in which the fantastic and the realistic are combined in a richly composed world of imagination, reflecting a continent's life and conflicts".
In his Nobel speech, Garcia Marquez said it was the "outsized reality" of brutal dictatorships and civil wars in Latin America, "and not just its literary expression", that got the attention of the Swedish Academy of Letters.
His other famous books include Chronicle of a Death Foretold, The General in His Labyrinth and his autobiography Living to Tell the Tale. His final novel, Memories of My Melancholy Whores, was published in 2004.
Journalist, Castro friend
Garcia Marquez also left his mark in journalism, which he considered "the most beautiful profession in the world".
He founded the Ibero-American New Journalism Foundation in the Colombian port city of Cartagena in 1994. His first job was with Bogota's El Espectador newspaper, which published his first short story in 1947, paying him 800 pesos, or less than $0.50 per month.
He left for Europe after an article angered the military regime at the time, living in Geneva, Rome and Paris, where he finished the 1961 book No One Writes to the Colonel.
An admirer of Cuba's revolution, he became a correspondent for the communist island's Prensa Latina news agency in Bogota and New York. He forged a controversial friendship with Castro, who called him "a man with the goodness of a child and a cosmic talent".
But he also worked as an emissary between Castro and another powerful friend, then US president Bill Clinton, in the 1990s.
In Mexico, his circle of friends included renowned Mexican writers Octavio Paz and Carlos Fuentes.
"I write so that my friends will love me," the novelist quipped.
Garcia Marquez had a falling out with his friend Vargas Llosa that culminated with the Peruvian novelist punching him outside a Mexico City movie theater in 1976.
"We were completely stunned and astonished," Mexican writer Elena Poniatowska recalled in an interview.
Neither one ever revealed the pair had quarreled. But Vargas Llosa paid tribute to Garcia Marquez, saying: "His novels will survive him and continue gaining readers everywhere."