All the sectoral indices led by healthcare, realty and banking were trading in the negative zone with losses up to 0.39% in early trade.
The benchmark BSE Sensex opened over 100 points lower in early trade on Tuesday on selling in banking, oil and pharma stocks by investors amid weak global trends.
Investors were cautious ahead of October series expiry in the derivatives segment on Thursday, brokers said.
On Tuesday morning, Asian markets opened lower as stock fell after Monday's gains. Investors also practised caution ahead of central bank meetings in the US and Japan.
At 1011 hours, the 30-share barometer, which had lost 108.85 points on Monday, was trading down 84.28 points, or 0.32% at 27,273.22.
All the sectoral indices led by healthcare, realty and banking were trading in the negative zone with losses up to 0.39% in early trade.
Also, the NSE Nifty declined by 27.40 points or 0.33% to 8,233.15.
Housing finance major HDFC was down over 2% after it posted moderate growth in profit for the second quarter of 2015-16 fiscal.
Among major losers on BSE, oil major ONGC was down 2.5% and Lupin by 2.2%. Metal stocks Hindalco and Vedanta fell up to 2% while telecom major Bhari Airtel fell up to 1% in early trade.
ITC, Coal India and Tata Steel were also down up to 1%, dragging the broader index into negative zone.
On the other hand, auto stocks Maruti Suzuki, Bajaj Auto and Mahindra and Mahindra posted gains of up to 1%.
Brokers said offloading of positions by participants, tracking a weak trend at the other Asian markets as investors await the start of a US Federal Reserve meeting later in the day influenced sentiments.
In Asian markets, Hong Kong's Hang Seng was down by 0.93%, while Japan's Nikkei fell by 0.67% in early trade on Tuesday. Shanghai Composite index was down 2.09%.
The Dow Jones Industrial Average ended 0.13% lower on Tuesday.
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