Mammoth step: Dead rat revived after 16 yrs

Experts plan to restore species like the mammoth applying the same technique used on rats

TOKYO: Scientists at the government-backed research institute Riken used the dead cell of a mouse that had been preserved at minus 20 degrees Celsius (minus 4 degrees Fahrenheit) — a temperature similar to frozen ground.

The scientists hope that the first-of-a-kind research will pave the way to restore extinct animals such as the mammoth.

The scientists extracted a cell nucleus from an organ of the dead mouse and planted it into an egg of another mouse which was alive, leading to the birth of the cloned mouse, the researchers said.

“The newly developed technology of nucleus transfer greatly improved the possibility of reviving extinct animals,” the research team led by Teruhiko Wakayama said in a statement. “Even though reviving extinct animals is often described in films and novels — such as in Michael Crichton’s Jurassic Park — it had in reality been impossible,” they said.

Cells from dead bodies have previously been useless as they are ruined in the freezing process. But Wakayama’s team discovered a way to extract a nucleus intact from a frozen cell by grinding cell tissues into multiple pieces.The cloned mouse was able to reproduce with a female mouse, it added. But the researchers said tough challenges
remain ahead in terms of how to restore extinct animals, which would require breeding with animals that are still alive. To revive a mammoth, researchers would need to find a way to implant a cell nucleus of a mammoth into the egg of an elephant and then implant the embryo into an elephant’s uterus, it said.The elephant is the closest modern relative of the mammoth.

 Earlier this year, a report by the European Union warned that cloning can threaten the health of livestock.

South Korea’s parliament has passed a law to regulate research into cloning, following a scandal in which a now disgraced expert falsely claimed to have made the first human clone stem cells.