A shopping centre in Manchester, England, was evacuated and witnesses said they heard a "big bang" on Tuesday, just hours after a suicide bomber killed 22 people and injured 59 in the same area of the city.

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Scores of people ran away from the centre, a Reuters witness said.

"There are people coming out holding hands," a Reuters photographer said.

Police in the northern English city of Manchester are investigating an incident at the Arndale shopping centre in the centre of the city, an officer at the scene said on Tuesday.