Interpol has issued a "red notice", the closest instrument to an international arrest warrant, on four North Korean suspects wanted in connection with the murder of Kim Jong Nam, Malaysia's police chief said on Thursday.

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Kim Jong Nam, the estranged half-brother of North Korean leader Kim Jong Un, was killed on February 13, when Malaysian police say two women smeared super toxic VX nerve agent on his face at Kuala Lumpur International Airport.

Police requested Interpol's help last month to apprehend North Korean suspects who they believed had fled Malaysia shortly after the murder. They have identified seven North Korean wanted in connection with the murder, including four who are believed to have made their way back to Pyongyang.