An explosion has killed four people at a home in a Mexico City suburb where a massive fireworks market blast left dozens dead in December.

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The Mexico state government identifies the victims as two women aged 25 and 26 and two children aged 6 and 11. Six others were hospitalised for injuries from cuts to severe burns.

The local Red Cross says the explosion was "apparently due to a gas build-up."

The morning blast took place in a residential neighborhood of Tultepec, about 3 kilometers from the San Pablito fireworks market.

Many Tultepec residents make a living from the manufacture and sale of fireworks. It was not immediately clear whether there was explosive material at the residence that could have exacerbated the effects of the explosion.