Genetic links to kidney disease, kidney failure identified

Researchers at the Translational Genomics Research Institute (TGen) have identified genetic links to kidney disease and kidney failure.

The scientists have described their research in two presentations at this week's 70th Scientific Sessions of the American Diabetes Association, June 25-29, in Orlando, Florida.

One presentation describes a DNA study of American Indians in Arizona, in which the research tea, discovered a genetic biomarker with a significant association to kidney failure.

The study showed "the strongest evidence" for association with End Stage Renal Disease (ESRD), or kidney failure, in marker rs13315275, and also found evidence of some lesser associations between ESRD and four other markers.

"This study could someday lead to better treatment options for those patients suffering from diabetic kidney disease. We are conducting ongoing studies to further investigate these markers, and potentially what they might mean for the development of new therapeutics," said Dr Johanna DiStefano, Director of TGen's Diabetes, Cardiovascular and Metabolic Diseases Division, and lead author of the study's abstract.

All five biomarkers are genetic variants of the gene SUCNR1, which is located in a chromosomal region of the human genome identified as 3q24-q27. This region has been linked to diabetic nephropathy (DM), or diabetic kidney disease, in previous studies.

SUCNR1 is a receptor gene that acts on succinate in the kidneys to mediate the rennin-angiotensin system (RAS), a hormone system that helps control the body's blood pressure and fluid balance. High blood pressure can damage the heart, kidneys and exacerbate the harmful effects of diabetes.

Past studies have shown that diabetes is relatively high among Arizona's Native American communities.

In another TGen study, researchers initiated an investigation into the ways that the PVT1 gene impacts development of diabetic kidney disease.

Previous studies have shown an association between PVT1 and kidney failure in patients with diabetes, both autoimmune (type 1) and that most commonly caused by excessive weight, poor diet and lack of exercise (type 2).

In the new study, researchers found that PVT1 was expressed in mesangial cells, which are specialized cells around blood vessels in the kidneys, at a rate up to five times higher in conditions of high glucose (high blood sugar), compared to normal glucose levels. High blood sugar is a signature symptom of diabetes.

Dr. Lucrecia Alvarez, a TGen Post-Doctoral Fellow and the first author of the study's abstract, said: "These findings show that additional study of the role of PVT1 in diabetic kidney disease is well-justified."