Top-seeded Briton Andy Murray was knocked out of the Australian Open in the fourth round on Sunday, losing 7-5 5-7 6-2 6-4 to German world number 50 Mischa Zverev on Rod Laver Arena.

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Murray's defeat follows that of reigning champion Novak Djokovic, who fell to Denis Istomin in the second round on Thursday, leaving the men's draw at the year's first grand slam without its top two seeds at the quarter-final stage.

World number 50 played close to the net when the situation demanded it. This forced Murray to make numerous errors.

Zverev took the first set from a break down, but Murray leveled the field with superb performance. But the German took the lead with a comfortable third set.

The 29-year-old broke Murray again in the opening game of the fourth set and held firm on serve under a barrage of pressure to seal the biggest win of his career.

At world rank 50, Zverev is the lowest-ranked player to beat a top seed at a slam since then world number 86 Marat Safin defeated Andy Roddick at 2004 Australian Open quarter-finals.

(With Reuters Inputs)