Researchers found that 95.7% of the persons part of the study had 50 times more neutralising antibodies 10 days after the third COVID-19 vaccine dose.
A recently published study from Israel found 50-fold increase in neutralising antibodies in healthcare workers after taking a third dose of their COVID-19 vaccine around eight months after their second dose.
The report published today in the Lancet Microbe journal provides details of the study which examined 346 healthy healthcare workers who took their booster dose of the Pfizer COVID-19 vaccine.
The lead authors of the report are Esther Saiag and and Dr David Bomve from the Tel Aviv Sourasky Medical Center.
Saiag told a leading Israeli newspaper, “Healthcare workers are very unique,” adding that they tend to be healthier and more active than average people.
With their crucial roles during the COVID-19 pandemic, healthcare workers were among the first takers of the vaccines in almost every country.
Most of the persons part of the study had received their second doses of the COVID-19 vaccine around eight months before the booster dose.
The authors of the study had asked healthcare workers to allow themselves to be screened for antibody levels before taking the third dose. 346 people came forward in the age group of 64 to 73. While 215 are women, 131 are men.
The people participating in the study returned to get their antibody levels checked 10 days after the third dose. The researchers found that 95.7% of the individuals had around 50 times more neutralising antibodies.
Saiag said, “We saw that very soon after having enough of the population getting the third booster that the fourth wave subsided. Now we see what was happening behind the scenes. We have this surge in antibodies. Maybe we all expected to find this, but now we have the data to prove it.”
Out of all the subjects of the research, only two persons did not show the surge in antibody levels and showed negative levels. A minor number of people showed only a moderate increase in antibodies, in spite of the third dose.
The researchers will now initiate a follow-up study to find out the possible causes for the low or negative response to booster dose among some people in the study.
The study is the largest of its kind analysing the impact of the COVID-19 vaccine booster dose on healthcare workers.
The people part of the study will undergo continuous screenings at 6, 8 and 10 months after the third dose. As per the lead author, the findings of the study could be beneficial to governments in making the decisions related to booster doses of the COVID-19 vaccine.
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 "Third dose of COVID-19 vaccine leads to 50 times more antibodies, says new Israeli study")
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