Structural errors in proteins responsible for complex life

Researchers have said that tiny structural errors in proteins may have been responsible for changes that sparked complex life.A comparison of proteins across 36 modern species suggests that protein flaws called "dehydrons" may have made proteins less stable in water.This would have made them more adhesive and more likely to end up working together, building up complex function.The study adds weight to the idea that natural selection is not the only means by which complexity rises, reported the BBC.Natural selection is a theory with no equal in terms of its power to explain how organisms and populations survive through the ages; random mutations that are helpful to an organism are maintained while harmful ones are bred out.But the study provides evidence that the "adaptive" nature of the changes it wreaks may not be the only way that complexity grew.Single-celled life gave rise to more complex organisms, and with them came ever-more complicated networks of gene and protein interactions.Michael Lynch, an evolutionary theorist at Indiana University, teamed up with Ariel Fernandez of the University of Chicago, both in the US, to look specifically at protein structure.They considered 106 proteins shared among 36 modern-day organisms of widely varying complexity, from single-celled protozoa up to humans."We've tried to bridge the gap between protein structure and evolution and believe we've uncovered evidence that proteins develop mild defects in organisms with smaller population sizes, over the great divide from bacteria to unicellular eukaryotes to invertebrates up to us vertebrates," BBC quoted Lynch as saying.The study is detailed in Nature.