American actor Leonardo DiCaprio and director Martin Scorsese will team up for the sixth time for the big screen adaptation of Erik Larson's book The Devil in the White City.

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The 40-year-old actor, who had purchased the film rights back in 2010, will play the role of Dr HH Holmes, a serial killer, who has killed 27 people and uses the 1893 World's Fair in Chicago to lure his victims to their deaths, the BBC reported.

Previously, the duo had worked together in films such as The Wolf of Wall Street, The Departed, Gangs of New York and Murder castle.

The upcoming venture will narrate the story of Dr Holmes, who converted a large building in Chicago into a murder castle with a padded room and a gas pipe to asphyxiate victims, a chute for dispatching bodies to the cellar and in the cellar, a hidden butcher's table and an oven that had the remains of women's clothing.

Hunger Games' Billy Ray will pen the screenplay.

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