Key indices on Thursday opened in red, while Sensex nosedived 150 points. Nifty too opened in red. At 9:48 AM, Sensex was down 179.58 points to trade at 33,422.70 and Nifty detoriated to 59.50 points to trade at 10,301.55. 

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The markets were negative ahead of expiry of November derivative contracts. Investors also await second quarter GDP data and OPEC decision later today.

Among the early losers were Vedanta, Tech Mahindra, Axis Bank, UltraTech Cement, SBI, Kotak Mahindra Bank, Adani Ports, Tata Motors and Reliance Industries. 

Sun Pharma, Indiabulls Housing Finance, Bosch, IndusInd Bank, Wipro and Aurobindo Pharma were early gainers.

Nifty Midcap was down 0.4 percent. Future Retail, McLeod Russel, Balaji Telefilms, GNA Axles, Indiabulls Real, Puravankara, Delta Corp and Gati were down 1-4 percent.

TBZ fell 9 percent and Mukta Arts gained 13 percent post earnings.

Asian shares fell on Thursday, weighed down by a plunge in high-flying technology shares, a move that some see as a healthy correction after a strong rally but others believe may herald the peak of a "super cycle" that has been boosting the sector.

MSCI's broadest index of Asia-Pacific shares outside Japan dropped 0.9 percent, with technology bellwether Samsung Electronics falling 2.9 per cent to two-month lows and Taiwan's TSMC down 1.9 per cent.

Japan's Nikkei dipped 0.1 percent, led by a 2.0 per cent fall in electronic machinery makers.

In the U.S., the Nasdaq Composite dropped 1.27 per cent as investors shifted to financials and other sectors even as the S&P 500 was almost flat and the Dow Jones Industrial Average gained 0.44 percent.

Shares of Amazon.com, Apple, Google parent Alphabet and Facebook fell between 2 per cent and 4 per cent. Among the year's other high fliers, Netflix slid 5.5 percent.

Possibly weighing on them were concerns, sparked by a Morgan Stanley report earlier this week, that "super-cycle" in memory chip demand is likely to peak soon.