Hardest-hit so far has been Brazil, with more than 1.5 million cases since April.
Guatemalan health officials have said that at least 105 people had been infected with Zika, the virus suspected of causing grave brain damage in newborns.
Health Ministry epidemiologist Judith Garcia told the newspaper Prensa Libre on Saturday that the 105 confirmed cases emerged from a total of 200 suspected cases, 68 of them from 2015. For each confirmed case, Garcia said, there may be three more patients who have not come forward or who are asymptomatic, meaning the ultimate numbers could be much larger.
Zika is transmitted by the Aedes aegypti mosquito, which also spreads dengue fever and the chikungunya virus. It provokes flu-like symptoms including a low-grade fever, headaches, joint pain and rashes. "Guatemala's humid climate is quite favourable" to the virus, said Garcia.
The World Health Organisation (WHO) warned this week that the virus is "spreading explosively" in the Americas, with three million to four million cases expected in 2016. Hardest-hit so far has been Brazil, with more than 1.5 million cases since April.
On Tuesday, Barack Obama called for the rapid development of tests, vaccines and treatments to fight the mosquito-transmitted Zika virus
Health authorities there are investigating the possible linkage between Zika and more than 3,400 suspected cases of microcephaly -- abnormally small skulls and brains -- in babies born to infected mothers. Colombia announced earlier on Saturday that it has 20,297 cases of Zika infection, including 2,116 in expectant mothers.
Zika is present in 21 countries in Latin America and the Caribbean, according to WHO experts. It was detected for the first time in Uganda in 1947 and was named after a forest south of that nation's capital of Kampala.
Meanwhile, the US officials say they have two potential candidates for a vaccine for the virus and may begin clinical trials in people by the end of 2016, but there will not be a widely available vaccine for several years.
Read: More research needed into Zika-microcephaly link - Scientists
Also Read: Here is all you need to know about the Zika virus and the current outbreak
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 "A doctor extracts blood from a pregnant woman suspected to be infected with Zika, at the maternity ward of a hospital in Guatema")
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