Clarke re-injured his problematic left hamstring in Australia's 23-run win over the Proteas at Perth.
Australia captain Michael Clarke will miss the rest of the ODI series against South Africa, thanks to a hamstring injury, the country's cricket board (CA) said on Saturday.
Clarke re-injured his problematic left hamstring on Friday, in Australia's 23-run win over the Proteas at Perth, and had scans on Saturday.
"Michael had scans today in Perth for his ongoing left hamstring problem and as a result has been ruled out of the remaining matches in the... ODI Series," CA team doctor Peter Brukner said in a statement.
"Michael will return to Sydney for further treatment and an update on his fitness for the first test in Brisbane will be made in due course."
Perth also hosts the second game on Sunday, with George Bailey confirmed to lead the home side, a role he is set to continue to play in the five-match series.
Clarke's injury sidelined him for the entire ODI series against Pakistan, in the United Arab Emirates, and almost all of a preceding ODI tournament, against South Africa and hosts Zimbabwe.
The recurrence of the injury has stoked fears Australia could head into a four-test series against India, without their top batsman and master tactician, while another breakdown could be the end of his World Cup ambitions.
The first test against India will start on December 4.
Australia coach Darren Lehmann confirmed Clarke would be replaced by middle order batsman Steven Smith.
Bailey led the team after Clarke was ruled out midway through the match.
Lehmann said Australia could win the World Cup with or without Clarke.
"It's never easy when you're losing one of your best players, but that's part and parcel of sport these days," Lehmann told reporters in Perth on Saturday.
"Players have got to be adaptable.
"We'd love him there. But you can (still) win every game you play (without him).
"With the 11 that go on the field, we have full faith in winning each and every game," added Lehmann.
With ever injury breakdown, Australian media have called on Clarke to step down as ODI captain to prolong his career in tests, considered by far the most important format in Australia.
Pundits repeated the calls in newspapers on Saturday.
Lehmann said it would be Clarke's call as to whether he continued in the role.
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