New compound reverses Alzheimer’s symptoms

Researchers, including one of Indian origin, have claimed that a small molecule called TFP5 rescues plaques and tangles by blocking an overactive brain signal, thereby restoring memory in mice with Alzheimer’s disease (AD).

A new study by NIH researchers shows that when a molecule called TFP5 is injected into mice with a disease that is the equivalent of human Alzheimer's, symptoms are reversed and memory is restored, without obvious toxic side effects.

“We hope that clinical trial studies in AD patients should yield an extended and a better quality of life as observed in mice upon TFP5 treatment,” Harish C Pant from National Institute of Neurological Disorders at Stroke said.

“Therefore, we suggest that TFP5 should be an effective therapeutic compound,” he said.

To make this discovery, Pant and colleagues used mice with a disease considered the equivalent of Alzheimer's.
One set of these mice were injected with the small molecule TFP5, while the other was injected with saline as placebo.

The mice, after a series of intraperitoneal injections of TFP5, displayed a substantial reduction in the various disease symptoms, along with restoration of memory loss.

In addition, the mice receiving TFP5 injections experienced no weight loss, neurological stress (anxiety) or signs of toxicity.
The disease in the placebo mice, however, progressed normally as expected. TFP5 was derived from the regulator of a key brain enzyme, called Cdk5.

The over activation of Cdk5 is implicated in the formation of plaques and tangles, the major hallmark of Alzheimer’s disease.
The study has been published in the FASEB Journal.