Barrymore, who gave birth to daughter Olive in September last year, has been trying to manage things since then.
"I was raised in that generation of women can have it all, and I don’t think you can. I think some things fall off the table. The good news is, what does stay on the table becomes much more in focus and much more important," usmagazine.com quoted Barrymore as saying.
"It sucks when you’ve worked really hard for certain things and you have to give them up because you know that you’re going to miss out on your child’s upbringing, or you realise that your relationship has suffered," she added.